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Breakthrough in treating neurological conditions

Reprogramming of equine keratinocytes: A, B) Equine epidermal explants (A, upper and lower panels) were  used to derive primary keratinocyte cultures (B, upper and lower panels). Upper panel in (A) shows Trichrome Mason’s staining of parental equine  epidermis. Lower panels in (A, B) show pan-cytokeratin (P-CK) staining (labelled with Alexa flour 488) of parental epidermal explants and keratinocyte monolayers.

Reprogramming of equine keratinocytes: A, B) Equine epidermal explants (A, upper and lower panels) were used to derive primary keratinocyte cultures (B, upper and lower panels). Upper panel in (A) shows Trichrome Mason’s staining of parental equine epidermis.

Horses suffering from neurological conditions similar to those that affect humans could be helped by a breakthrough from stem-cell scientists in Edinburgh, Scotland.

Researchers – the first to create working nerve cells from horse stem cells – say the advance may pave the way for cell therapies that target conditions similar to motor neurone disease.

The research could also benefit horses affected by grass sickness, a neurological condition that affects about 600 horses a year in Britain.

Little is known about the disease, which causes nerve damage throughout the body. It is untreatable and animals with the most severe form usually die or have to be put down.

The advance by the University of Edinburgh’s Roslin Institute will provide a powerful tool for those studying horse diseases. It will also help scientists to test new drugs and treatments.

The researchers took skin cells from a young horse and turned them into stem cells using a technique that was originally developed for human cells. The reprogrammed cells are pluripotent, meaning they can be induced to become any type of cell in the body.

The team used them to create nerve cells in the laboratory and tested whether they were functional by showing that they could transmit nerve signals.

Horse stem cells have been produced in the laboratory before, but this is the first time that scientists have created working cells of a specific type from them.

The results of their research has been published in the journal, Stem Cells and Development.

Vets around the world are already using stem-cell therapies to treat horses for other types of conditions.

The effectiveness of these treatments has not been completely proven and they use adult stem cells, which are harder to maintain and are more restricted in the types of cells that they can become. The approach is mostly used to treat tendon, ligament and joint problems.

The study was carried out by Dr Ruchi Sharma and Dr Xavier Donadeu.

“Stem cells hold huge therapeutic potential both for people and animals,” Dr Donadeu said.

“Our research is an important step towards realising that potential for horses and provides an opportunity to validate stem-cell-based therapies before clinical studies in humans.”

The research paper cand be read here.

Horsetalk.co.nz

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